Posts in Category: SCIB1

SCIB1: First patient treated in Phase II clinical trial

Scancell Holdings Plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, is pleased to announce the recruitment and treatment of the first patient in the second part of its Phase I/II clinical trial of SCIB1, its DNA ImmunoBody® vaccine being developed for the treatment of melanoma. The Phase II part of the trial will be conducted in five UK centres in thirteen patients with Stage III/IV disease to further assess the safety of treatment and to assess the cellular immune response induced by SCIB1. Patients will be treated with a 4mg dose of SCIB1 on five occasions over a period of 6 months. The study is expected to take 18 months to complete. 

Professor Lindy Durrant, Joint CEO of Scancell Holdings and Professor of Cancer Immunotherapy at Nottingham University, commented: 

“Although the recruitment of patients to early stage cancer studies can be very challenging, we expect recruitment for the Phase II part of the study to be substantially faster than for Phase I as we will not be constrained by the cohort study design required for dose escalation, there are more patients available and they are likely to have earlier stage disease.” 

For further information contact:

Scancell Holdings Plc  Dr Richard Goodfellow / Professor Lindy Durrant  + 44 (0)20 7653 9850* 
Newgate Threadneedle (Financial PR)  Graham Herring / Heather Armstrong  + 44 (0)20 7653 9850 
Zeus Capital - Nominated Adviser/Joint Broker  Ross Andrews/Tom Rowley  + 44 (0)161 831 1512 
XCAP - Joint Broker  Jon Belliss/ Adrian Kirk  +44 (0)207 101 7070 

*calls to this number will reach Newgate Threadneedle, at Scancell’s instruction. 

About Scancell 

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1 is being developed for the treatment of melanoma and is currently in Phase II clinical trials. 

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of 

the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells. 

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations. 

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses. 

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases. 

SCIB1 Trial Update

Scancell Holdings Plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, is pleased to announce the completion of recruitment to the Phase I clinical trial of SCIB1, its DNA ImmunoBody® vaccine being developed for the treatment of melanoma. The trial is being conducted in five UK centres in patients with Stage III/IV disease, and it is anticipated that Phase II trials will commence in the next few weeks. 

Scancell has obtained approval from the Cohort Review Committee to commence the Phase II study using the 4mg dose, the highest dose used in the Phase I part of the study. The approval is based upon safety data collected after all patients have been treated for 6 weeks. The Phase I patients will continue to be treated and followed up for a total of 6 months. 

Professor Lindy Durrant, Joint CEO of Scancell Holdings and Professor of Cancer Immunotherapy at Nottingham University, commented: 

“The recruitment of patients to early stage cancer studies can be very challenging and it is a tribute to both the dedicated Scancell team and the efforts of our clinical investigators that we have now completed recruitment for the Phase I part of the study. We expect recruitment for Phase II to be substantially faster than for Phase I and hope to treat the first patient in this part of the study within the next few weeks.” 

For further information contact: 

Scancell Holdings Plc  Dr Richard Goodfellow / Professor Lindy Durrant  + 44 (0)20 7653 9850*
Newgate Threadneedle (Financial PR)  Guy McDougall / Heather Armstrong  + 44 (0)20 7653 9850 
Zeus Capital - Nominated Adviser/Joint Broker  Ross Andrews/Tom Rowley  + 44 (0)161 831 1512 
XCAP - Joint Broker  Jon Belliss/ Adrian Kirk 

+44 (0)207 101 7070 

*calls to this number will reach Newgate Threadneedle, at Scancell’s instruction

ImmunoBody® Patent Approved in US

Scancell Holdings plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, is pleased to announce that its protein ImmunoBody® vaccine patent has been approved in the United States. The patent, which has already been approved in Europe and Australia, will further strengthen Scancell’s IP position around its proprietary ImmunoBody® vaccine platform.

Scancell’s lead vaccine, SCIB1 is being developed for the treatment of melanoma and is currently in Phase I clinical trials. It is an innovative DNA vaccine being developed using Scancell’s ImmunoBody® technology. Phase 2 trials are due to start in Q2 2012.

Dr. Richard Goodfellow, Joint Chief Executive of Scancell, commented:

“The USA remains the most important market in which to commercialise our ImmunoBody ® vaccines. The award of this US patent confirms the innovative nature of the ImmunoBody ® platform and provides a sound basis on which to commercialise the technology in the US.  Scancell will continue building its growing portfolio of intellectual property in parallel with driving the clinical trial programme forward during 2012”.  

Enquiries:

For further information contact: 

Scancell Holdings Plc  Dr Richard Goodfellow / Professor Lindy Durrant  + 44 (0)20 7653 9850*
Newgate Threadneedle (Financial PR)  Guy McDougall / Heather Armstrong  + 44 (0)20 7653 9850 
Zeus Capital - Nominated Adviser/Joint Broker  Ross Andrews/Tom Rowley  + 44 (0)161 831 1512 
XCAP - Joint Broker  Jon Belliss/ Adrian Kirk 

+44 (0)207 101 7070 

*calls to this number will reach Newgate Threadneedle, at Scancell’s instruction

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1 is being developed for the treatment of melanoma and entered clinical trials in 2010.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

 The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

Interim Results for the six month period to 31 October 2011

Scancell Holdings plc (“Scancell” or the “Company” or the “Group”), the developer of therapeutic cancer and infectious disease vaccines based on its patented Immunobody® platform, is pleased to announce the interim results for the six month period ended 31st October 2011.

Highlights:

  • Sub-division of share capital and Placing to raise £1.73 million;
  • Development of new vaccine candidate for the treatment of lung cancer;
  • Phase 1 clinical trial of SCIB1 proceeded to highest dose level following safety review;
  • SCIB1 patent awarded; and
  • Change of board structure.

Post Period Highlights:

  • Receipt of second tranche payment of £2.85 million in November 2011 relating to the sale of a portfolio of antibodies to Arana Therapeutics.

For further information contact:

Scancell Holdings Plc
Dr Richard Goodfellow / Professor Lindy Durrant
=44 (0) 20 7653 9842*

Newgate Threadneedle (Financial PR)
Guy McDougall / Heather Armstrong
+44 (0) 20 7653 9842

Zeus Capital - Nominated Adviser / Joint Broker
Ross Andrews / Tom Rowley
+44 (0) 161 831 1512

XCAP - Joint Broker
Jon Belliss / Adrian Kirk
+44 (0) 207 101 7070

*calls to this number will reach Newgate Threadneedle at Scancell's instruction.

View the full results 

Confirmation of second tranche payment of £2.85 million from Arana Therapeutics

Scancell Holdings Plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, is pleased to announce that it has received confirmation from Cephalon, Inc that the condition relating to the second tranche payment from the sale of Scancell’s antibody portfolio to Arana Therapeutics in 2006 has now been satisfied. Scancell is therefore due to receive a further sum of £2.85 million (before any related tax and other costs are deducted) on 16 November 2011.

Background

On 1 December 2006, Scancell sold its portfolio of antibodies to Arana Therapeutics (then known as Peptech (UK) Limited and subsequently acquired by Cephalon, Inc, which itself is now owned by Teva Pharmaceutical Industries Limited). The consideration for the sale was a cash payment of £2 million, which was paid on completion of the sale, plus a possible further sum of £2.85 million gross which was payable when a milestone was achieved relating to the development of a drug derived from any of the antibodies which were the subject of the sale.

Confirmation that payment is due

Scancell has received confirmation from Cephalon, Inc that this milestone has been achieved and the condition for payment of the further sum of £2.85 million has therefore been satisfied.

The receipt of the second tranche payment is expected to trigger a payment to advisers of the Company and, under an executive incentivisation package agreed by the Board in June 2006, Professor Lindy Durrant, Dr Richard Goodfellow and Nigel Evans are entitled to receive gross bonuses calculated as a percentage of the net payment received by the Company. The total of these payments is not expected to exceed £450,000.

The £2.85 million gross proceeds from the second tranche payment will therefore be reduced by the payment of bonuses and adviser costs as noted above and does not take into account any corporation tax that may arise.

David Evans, Chairman of Scancell, said: "The confirmation that Scancell will receive the second tranche payment of £2.85 million from Arana Therapeutics is excellent news for the Company. We expect that the net funds to be received will enable the Company to complete the Phase I and Phase II clinical trials of our lead melanoma vaccine, SCIB1, without the need to raise further funds from Shareholders."

For further information contact:

Scancell Holdings Plc
Dr Richard Goodfellow / Professor Lindy Durrant
+44 (0)207 245 1100*

Hansard Group (Financial PR)
Adam Reynolds / Guy McDougall
+44 (0)207 245 1100

Zeus Capital - Nominated Adviser/Joint Broker
Ross Andrews / Tom Rowley
+44 (0)161 831 1512

XCAP - Joint Broker
John Belliss / Adrian Kirk
+44 (0) 207 101 7070

*this number will direct callers to Hansard Group, at Scancell's instruction.

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1, which entered clinical trials in 2010, is being developed for the treatment of melanoma.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

SCIB1: Patent Awarded

Scancell Holdings plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, announces that a composition of matter patent (European Patent number 2193803) has been granted for the Company’s lead vaccine, SCIB1. SCIB1 is being developed for the treatment of melanoma and is currently in Phase I clinical trials. It is an innovative DNA vaccine being developed using Scancell’s ImmunoBody® technology. This patent will protect the unique composition of the vaccine until March 2028.

Dr. Richard Goodfellow, Joint Chief Executive of Scancell, commented:

“This patent grant is a further important step in the development and commercialisation of SCIB1. Scancell will continue building its growing portfolio of intellectual property in parallel with driving the clinical trial programme forward during 2012”.

For further information contact:

Scancell Holdings Plc
Professor Lindy Durrant/Dr Richard Goodfellow
+44 (0)207 245 1100*

Hansard Group (Financial PR)
Adam Reynolds/Guy McDougall
+44 (0)207 245 1100

Zeus Capital - Nominated Adviser
Ross Andrews/Tom Rowley
+44 (0)161 831 1512

XCAP Securities Plc - Broker
John Belliss/Adrian Kirk
+44 (0) 207 101 7070

*this number will direct callers to Hansard Group, at the Company’s request.

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1, which entered clinical trials in 2010, is being developed for the treatment of melanoma.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

SCIB1: Safety Review and Dose Escalation

Scancell Holdings Plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, is pleased to announce that the  second group of patients receiving the 2mg dose of SCIB1 (its DNA ImmunoBody® vaccine being developed for the treatment of melanoma) in the Phase I clinical trial has been evaluated by the Cohort Review Committee.

Following review of the safety data from this mid-dose level group of three patients, the Cohort Review Committee has approved further escalation of the dose to 4mg and recruitment of the final group of patients as planned. 

The trial, which commenced in June 2010, is designed to evaluate the safety and tolerability of SCIB1 in patients with late stage melanoma and also to gather data on the effects of SCIB1 on tumour growth and cellular immune response. 

Professor Lindy Durrant, Joint CEO of Scancell Holdings and Professor of Cancer Immunotherapy at Nottingham University, commented: “We are pleased that the Cohort Review Committee has given us the go-ahead to escalate the dose of SCIB1 to the highest dose level. This data, combined with the recent recruitment of a fifth trial centre at Southampton demonstrates that we are continuing to make good progress in our Phase 1 study. We expect to commence the Phase 2 study in late 2011/early 2012 as planned.”

For further information contact:

Scancell Holdings Plc
Professor Lindy Durrant/Dr Richard Goodfellow
+ 44 (0)207 245 1100
   
Hansard Communications
Adam Reynolds/Guy McDougall
+ 44 (0)207 245 1100
   
Zeus Capital - Nominated Adviser
Ross Andrews/Tom Rowley
+ 44 (0)161 831 1512

XCAP Securities Plc - Broker
Jon Belliss/Parimal Kumar
+44 (0) 207 101 7070About Scancell

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1, which entered clinical trials in 2010, is being developed for the treatment of melanoma.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

Scancell develops new vaccine for the treatment of lung cancer

Scancell Holdings Plc, (AIM: SCLP), the developer of therapeutic cancer vaccines, announces that a treatment utilising a DNA vaccine based on its ImmunoBody® technology, in combination with Homspera®, an adjuvant developed by ImmuneRegen BioSciences, Inc.® has produced encouraging anti-tumour results in animal models.

The vaccine, known as SCIB2, stimulates immune responses to the lung cancer antigen NY-ESO-1 and may also have potential utility in oesophageal, liver, gastric, prostate, ovarian and bladder cancers. Unlike classical adjuvants, Homspera® did not enhance the SCIB2 systemic immune response but did make it more effective at the tumour site. This could have profound implications for cancer vaccine therapy.

Scancell is currently conducting a Phase I clinical trial utilising its SCIB1 vaccine which is being developed for the treatment of melanoma. SCIB1 is a novel DNA vaccine which is also being developed using Scancell’s patented ImmunoBody® technology. ImmunoBody® vaccines generate the high-avidity T-cells that kill cancer cells.

ImmuneRegen’s Homspera® has previously been found to synergise with SCIB1 in an animal model. Additionally, previous studies have demonstrated efficacy of Homspera® in enhancing immune responses to infectious disease vaccines, such as influenza.

Professor Lindy Durrant, Chief Executive Officer of Scancell, commented:

“These are outstanding results for Scancell and a significant milestone for the Company. The successful application of Scancell’s ImmunoBody® technology, in conjunction with Homspera®, provides further evidence that our ImmunoBody® vaccine has the potentially groundbreaking ability to augment the immune responses necessary to destroy cancer. We are delighted to be combining our efforts with ImmuneRegen and look forward to progressing our work further at this pivotal moment for Scancell. Shareholders will be kept fully updated with this significant breakthrough. In addition to this highly positive news, we have a number of other promising vaccine candidates in development, which we hope will be the subject of further announcements in due course”.

Hal Siegel Ph.D., Chief Scientific Officer of ImmuneRegen, commented:

“We are very pleased with our ongoing collaboration with Scancell and the results of their studies with Homspera® in conjunction with their ImmunoBody® technology. This is further evidence of the immunostimulatory activity of our compound, and also demonstrates a broader anti-tumour effect than previously reported. Furthermore, these recent studies suggest a specificity regarding the dendritic cell activity of Homspera that is both intriguing and promising. We are anticipating additional studies at Scancell will provide further insights into the activity and value of Homspera as an ImmunoBody® vaccine adjuvant for a potentially broad spectrum of therapeutic cancer treatments.”

ImmuneRegen BioSciences, Inc.® is a wholly owned subsidiary of IR BioSciences Holdings, Inc. (OTC BB:IRBS.OB)

For further information contact:

Scancell Holdings Plc
Professor Lindy Durrant
+ 44 (0)207 245 1100

Hansard Communications
Adam Reynolds/Guy McDougall
+ 44 (0)207 245 1100

Zeus Capital - Nominated Adviser
Ross Andrews/Tom Rowley
+ 44 (0)161 831 1512

XCAP Securities Plc - Broker
John Belliss/Parimal Kumar
+44 (0)207 101 7070

About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer and infectious diseases based on its groundbreaking ImmunoBody® technology platform. Scancell’s first cancer vaccine SCIB1, which entered clinical trials in 2010, is being developed for the treatment of melanoma.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

An ImmunoBody® is a human antibody or fusion protein engineered to express helper cell and CTL epitopes from tumour antigens over-expressed by cancer cells. Antibodies are ideal vectors for carrying T cell epitopes from tumour antigens as they have long half-lives and can effectively target dendritic cells via their Fc receptors, allowing efficient stimulation of both helper and CTL responses.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

Final Results for the Year Ended 30 April 2011

A Year of Significant Progress

Scancell Holdings plc, (‘Scancell’ or the ‘Company’) the developer of therapeutic cancer vaccines, announces results for the year ended 30 April 2011.

Highlights during the period:

  • Key development milestone reached with lead therapeutic melanoma vaccine SCIB1
    • Phase I/IIa clinical trials commenced 15 June 2010
  • Secured licensing agreements with:
    • The National Institutes of Health (an agency of the United States Department of Health and Human Services); and
    • Cancer Research Technology Ltd (Cancer Research UK's commercialisation and development arm)
  • Entered strategic collaborations with ImmuneRegen BioSciences, Inc and immatics biotechnologies GmbH
  • Loss before tax for the year of £1.72 million (2010: £1.8 million)
  • Cash at year end £1.1 million (not including the net proceeds from the Placing to be announced today)

To be announced today:

  • New lung cancer vaccine, SCIB2 – latest anti-tumour results in animal models provide further validation of ImmunoBody® vaccine technology platform and its commercial potential
  • Placing to raise £1.73 million (before costs) to fund the working capital of the Company
  • Appointment of Richard Goodfellow as Joint Chief Executive Officer

Professor Lindy Durrant, commented:

“We believe that, following completion of the Placing, we will have sufficient funding to complete the Phase I trials of our melanoma treatment and to advance the development of our series of new ImmunoBody® cancer vaccines to the pre-clinical proof of principle stage. After the Phase I clinical trial has been completed, and if the data is positive, the Company will seek to generate revenues from a commercial deal on the ImmunoBody® technology and will continue with the Phase II clinical trial. A successful outcome should present Scancell as an excellent acquisition opportunity with an exit remaining firmly on the agenda following the completion of the Phase II trial, expected early 2013.”

Enquiries:
Scancell Holdings Plc
Professor Lindy Durrant/Dr Richard Goodfellow
+ 44 (0)207 245 1100

Hansard Communications
Adam Reynolds/Guy McDougall
+ 44 (0)207 245 1100

Zeus Capital - Nominated Adviser
Ross Andrews/Tom Rowley
+ 44 (0)161 831 1512

View the full results (PDF file opens in a new window)

Unaudited Interim Results for the six month period to 31st October 2010

Scancell Holdings plc, the developer of therapeutic cancer and infectious disease vaccines based on its patented Immunobody® platform, is pleased to announce the interim results for the six month period ended 31st October 2010.

Highlights:

  • Successful progression of SCIB1, Scancell's lead vaccine for melanoma, which entered clinical trials in June 2010
  • Raised £2.5 million in April 2010 with new and current shareholders
  • Moved from PLUS to AIM in July 2010
  • Secured licensing agreements with:
    • the National Institutes of Health (an agency of the United States Department of Health and Human Services); and
    • Cancer Research Technology Ltd (Cancer Research UK's commercialisation and development arm)
  • Entered strategic collaborations with:
    • ImmuneRegen BioSciences, Inc.®; and
    • immatics biotechnologies GmbH

Post-period Highlights:

  • Four patients recruited to date for the clinical trials
  • Approval obtained to open a fourth UK patient recruitment site and to expand the patient population in the Phase I part of the study, to include all patients with Stage III and Stage IV malignant melanoma
  • Escalation of the dose and recruitment of the next group of patients in SCIB1 trial approved by the Cohort Review Committee

For further information contact:

Scancell Holdings Plc
Professor Lindy Durrant
+ 44 (0)207 245 1100

Hansard Communications
Kirsty Corcoran/Adam Reynolds
+44 (0)207 245 1100

Zeus Capital - Nominated Adviser/Joint Broker
Ross Andrews/Tom Rowley
+ 44 (0)161 831 1512

Matrix Corporate Capital LLP - Joint Broker
Robert Naylor/Stephen Waterman

View the full results