Immunobody®
ImmunoBody® is a customisable DNA vaccine engineered to express epitopes from a cancer antigen whilst retaining the ability to target activated antigen presenting cells in vivo. This tumour- targeted, dual action approach, has shown clinical efficacy in advanced melanoma.
SCIB1/iSCIB1+ is Scancell’s lead ImmunoBody® vaccine
SCIB1/iSCIB1+ encodes a protein in the form of a modified antibody, which is engineered to express gp100 and TRP-2 epitopes whilst retaining the ability to target activated antigen presenting cells in vivo. Currently in clinical development for the treatment of patients with metastatic melanoma, SCIB1 has demonstrated durable potent anti-tumour responses in combination with checkpoint inhibitors and as a monotherapy. iSCIB1+ has enhanced potency and efficacy through the incorporation of more tumour epitopes. Supported by a robust GMP manufacturing process and a stable shelf life, SCIB1 offers a fast route to treatment for patients.
TUMOUR TARGETED
SCIB1/iSCIB1+ ImmunoBody® incorporates specific epitopes from the proteins gp100 and TRP-2 which play key roles in the production of melanin in the skin and were identified from T cells of patients who achieved spontaneous recovery from melanoma skin cancers.
DUAL ACTION
Direct and indirect Fc targeting via CD64 of activated dendritic cells initiates direct and cross-presentation of epitopes to T cells resulting in higher T cell avidity of up to 100-fold increased potency and increased number of T cells to tumour epitopes.
LOW TOXICITY
Favorable safety and tolerability alone or when added to checkpoint inhibitor treatment with potent vaccine specific T cell responses
Targets antigen presenting cells in vivo to give potent T cell responses, attacking cancer on multiple fronts.
Robust GMP manufacturing process, stable shelf life and faster route to treatment allowing pricing flexibility. Five-year stability.
Delivers a spring-powered injection in 0.1 seconds by means of a narrow stream of fluid that penetrates the skin with a precise dose and depth.
Favourable safety profile when administered as a monotherapy and in combination with checkpoint inhibitors
DNA targets can be adapted to target other cancers. Groundbreaking science leads to validated preclinical results and rapid entry into the clinic.
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